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Article

Characterization of the Specific Interactions between Nanoparticles and Proteins at Residue-Resolution by Alanine Scanning Mutagenesis.

ACS applied materials & interfaces - 5 Aug 2020

Luo Lei, Liu Yuan-Yuan, Gao Tiange, Wang Xinping, Chen Jingqi, Wang Haifang, Liu Yuanfang, Cao Aoneng

Abstract excerpt

The interaction between nanoparticles and proteins is a central problem in the nano-bio-fields. However, it is still a great challenge to characterize the specific interaction between nanoparticles and proteins in structural details. Using the Goldbodies, the artificial antibodies created by grafting complementary-determining regions (CDRs) of natural antibodies onto gold nanoparticles, as the models, we manage...

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PMID: 32672033
DOI: 10.1021/acsami.0c05994

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