Article
Engineering protein farnesyltransferase for enzymatic protein labeling applications.
Bioconjugate chemistry - 16 Jul 2014
Dozier Jonathan K, Khatwani Santoshkumar L, Wollack James W, Wang Yen-Chih, Schmidt-Dannert Claudia, Distefano Mark D
Abstract excerpt
Creating covalent protein conjugates is an active area of research due to the wide range of uses for protein conjugates spanning everything from biological studies to protein therapeutics. Protein Farnesyltransferase (PFTase) has been used for the creation of site-specific protein conjugates, and a number of PFTase substrates have been developed to facilitate that work. PFTase is an effective catalyst for protein...
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