Article

The Genetic Basis of Transcriptional and Spatial Heterogeneity of Squamous Features in Pancreatic Ductal Adenocarcinoma

2019-02-14

Abstract excerpt

<h4>Summary</h4> Recent studies indicate that pancreatic cancer expression profiles are variable and largely reflect a classical or basal-type phenotype. We performed genetic sequencing, RNA-seq, and histologic review of multiregion sampled pancreatic cancers and found that squamous and squamoid features, indicators of poor prognosis, correlate with a “basal-like” expressional type. Cancers with squamous features...

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Literature Corpus work: 51ce28db-e8be-565d-8a44-5a3a71fca403
DOI: 10.1101/548354

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