Article
A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jan 2020
Covés-Datson Evelyn M, King Steven R, Legendre Maureen, Gupta Auroni, Chan Susana M, Gitlin Emily, Kulkarni Vikram V, Pantaleón García Jezreel, Smee Donald F, Lipka Elke, Evans Scott E, Tarbet E Bart, Ono Akira, Markovitz David M
Abstract excerpt
There is a strong need for a new broad-spectrum antiinfluenza therapeutic, as vaccination and existing treatments are only moderately effective. We previously engineered a lectin, H84T banana lectin (H84T), to retain broad-spectrum activity against multiple influenza strains, including pandemic and avian, while largely eliminating the potentially harmful mitogenicity of the parent compound. The amino acid...
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