Article

A genetically engineered therapeutic lectin inhibits human influenza A virus infection and sustains robust virus-specific CD8 T cell expansion

2024-08-17

Abstract excerpt

<h4>ABSTRACT</h4> Native banana lectin (BanLec) is antiviral but highly mitogenic, which limits its therapeutic value. In contrast, the genetically engineered H84T BanLec (H84T) is not mitogenic but remains effective against influenza A virus (IAV) infection in mouse models. However, the potency and effect of H84T on human immune cells and IAV-specific immune responses is undetermined. We found that H84T efficien...

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Literature Corpus work: 0d5fddd3-9e0a-5aba-bb99-d9471ab0a94a
DOI: 10.1101/2024.08.15.608041

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