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Article

Glycan shielding of the influenza virus hemagglutinin contributes to immunopathology in mice.

American journal of respiratory and critical care medicine - 15 Mar 2011

Wanzeck Keith, Boyd Kelli L, McCullers Jonathan A

Abstract excerpt

RATIONALE: Pandemic influenza viruses historically have had few potential sites for N-linked glycosylation on the globular head of the hemagglutinin (HA) on emergence from the avian reservoir. Gain of glycans within antigenic sites of the HA during adaptation to the mammalian lung facilitates immune evasion. OBJECTIVES: In this study, we sought to determine in mice how exposure to highly glycosylated viruses...

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Share to Glycosylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Influenza A Virus, H1N1 Subtype

Share to Influenza A Virus, H3N2 Subtype

Share to Mice, Inbred BALB C

Share to Orthomyxoviridae Infections

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Source

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Identifiers

PMID: 20935106
DOI: 10.1164/rccm.201007-1184OC
PMCID: PMC3159075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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