Article

A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo

2021-05-17

Abstract excerpt

<title>Abstract</title> <p>Coronaviruses have repeatedly crossed species barriers to cause epidemics<sup>1</sup>. “Pan-coronavirus” antivirals targeting conserved viral components involved in coronavirus replication, such as the extensively glycosylated spike protein, can be designed. Here we show that the rationally engineered H84T-banana lectin (H84T-BanLec), which specifically recognizes high-mannose found on...

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Identifiers and source

Literature Corpus work: 57a72c58-7883-5743-aa9c-c74dc47a4d37
DOI: 10.21203/rs.3.rs-516695/v1

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