Article
The glycosylation status of the murine hepatitis coronavirus M protein affects the interferogenic capacity of the virus in vitro and its ability to replicate in the liver but not the brain.
Virology - 1 Aug 2003
de Haan Cornelis A M, de Wit Marèl, Kuo Lili, Montalto-Morrison Cynthia, Haagmans Bart L, Weiss Susan R, Masters Paul S, Rottier Peter J M
Abstract excerpt
The coronavirus M protein, the most abundant coronaviral envelope component, is invariably glycosylated, which provides the virion with a diffuse, hydrophilic cover on its outer surface. Remarkably, while the group 1 and group 3 coronaviruses all have M proteins with N-linked sugars, the M proteins of the group 2 coronaviruses [e.g., mouse hepatitis virus (MHV)] are O-glycosylated. The conservation of the N- and...
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