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Article

Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus.

Biochimica et biophysica acta. General subjects - 1 Apr 2020

Noske Gabriela Dias, Gawriljuk Victor Oliveira, Fernandes Rafaela Sachetto, Furtado Nathalia Dias, Bonaldo Myrna Cristina, Oliva Glaucius, Godoy Andre Schutzer

Abstract excerpt

BACKGROUND: The Yellow Fever virus (YFV) is transmitted by mosquitos and causes an infection with symptoms including fever, headaches and nausea. In 20-50% of the cases, the disease may evolve to a visceral stage, reaching high mortality rates. YFV NS2B-NS3 protease has been identified as an important drug target. METHODS: Herein, we describe the crystal structure of the NS2B-NS3 protease from the 2017 YFV...

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Identifiers

PMID: 31931019
DOI: 10.1016/j.bbagen.2020.129521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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