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Article

Site-directed mutagenesis and kinetic studies of the West Nile Virus NS3 protease identify key enzyme-substrate interactions.

The Journal of biological chemistry - 28 Jan 2005

Chappell Keith J, Nall Tessa A, Stoermer Martin J, Fang Ning-Xia, Tyndall Joel D A, Fairlie David P, Young Paul R

Abstract excerpt

The flavivirus West Nile virus (WNV) has spread rapidly throughout the world in recent years causing fever, meningitis, encephalitis, and fatalities. Because the viral protease NS2B/NS3 is essential for replication, it is attracting attention as a potential therapeutic target, although there are currently no antiviral inhibitors for any flavivirus. This paper focuses on elucidating interactions between a...

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Identifiers

PMID: 15494419
DOI: 10.1074/jbc.M409931200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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