Article
Polymorphism of the Cysteine Protease YopT from Yersinia pestis.
Protein and peptide letters - 1 Jan 2016
Platonov Mikhail E, Svetoch Tat'yana E, Evseeva Vera V, Knyazeva Anastasiya I, Dentovskaya Svetlana V, Motin Vladimir L, Uversky Vladimir N, Anisimov Andrey P
Abstract excerpt
Antibiotic therapy of plague is hampered by the recent isolation of Yersinia pestis strain resistant to all of antibiotics recommended for cure. This has constrained a quest for new antimicrobials taking aim at alternative targets. Recently Y. pestis cysteine protease YopT has been explored as a potential drug target. Targets conserved in the pathogen populations should be more efficacious; therefore, we...
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