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Article

A comparative biochemical analysis of the NS2B(H)-NS3pro protease complex from four dengue virus serotypes.

Biochimica et biophysica acta - 1 Jan 2000

Iempridee Tawin, Thongphung Ratchanu, Angsuthanasombat Chanan, Katzenmeier Gerd

Abstract excerpt

The two-component protease NS2B-NS3 of dengue virus mediates proteolytic processing of the polyprotein precursor and therefore represents a target for the development of antiviral drugs. The amino acid sequences of the NS3 serine protease and the NS2B cofactor exhibit relatively low degrees of conservation among the 4 serotypes thus suggesting that differences in enzyme activity exist which could modulate their...

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PMID: 18439431
DOI: 10.1016/j.bbagen.2008.03.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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