Article
c-Myc regulates cell proliferation during lens development.
PloS one - 1 Jan 2014
Cavalheiro Gabriel R, Matos-Rodrigues Gabriel E, Gomes Anielle L, Rodrigues Paulo M G, Martins Rodrigo A P
Abstract excerpt
Myc protooncogenes play important roles in the regulation of cell proliferation, growth, differentiation and survival during development. In various developing organs, c-myc has been shown to control the expression of cell cycle regulators and its misregulated expression is detected in many human tumors. Here, we show that c-myc gene (Myc) is highly expressed in developing mouse lens. Targeted deletion of c-myc...
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