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Article

Sexual dimorphism in the response to chronic circadian misalignment on a high-fat diet

17 May 2023

Abstract excerpt

Longitudinal studies associate shiftwork with cardiometabolic disorders but do not establish causation or elucidate mechanisms of disease. We developed a mouse model based on shiftwork schedules to study circadian misalignment in both sexes. Behavioral and transcriptional rhythmicity were preserved in female mice despite exposure to misalignment. Females were protected from the cardiometabolic impact of circadian...

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PMID: 37196066
DOI: 10.1126/scitranslmed.abo2022

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