Article
A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice.
Genetics - 1 Mar 2020
Bubier Jason A, Philip Vivek M, Quince Christopher, Campbell James, Zhou Yanjiao, Vishnivetskaya Tatiana, Duvvuru Suman, Blair Rachel Hageman, Ndukum Juliet, Donohue Kevin D, Foster Carmen M, Mellert David J, Weinstock George, Culiat Cymbeline T, O'Hara Bruce F, Palumbo Anthony V, Podar Mircea, Chesler Elissa J
Abstract excerpt
The microbiome influences health and disease through complex networks of host genetics, genomics, microbes, and environment. Identifying the mechanisms of these interactions has remained challenging. Systems genetics in laboratory mice (Mus musculus) enables data-driven discovery of biological network components and mechanisms of host-microbial interactions underlying disease phenotypes. To examine the interplay...
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