Article
Solid-type poorly differentiated adenocarcinoma of the stomach: Deficiency of mismatch repair and SWI/SNF complex.
Cancer science - 1 Mar 2020
Tsuruta Shinichi, Kohashi Kenichi, Yamada Yuichi, Fujiwara Minako, Koga Yutaka, Ihara Eikichi, Ogawa Yoshihiro, Oki Eiji, Nakamura Masafumi, Oda Yoshinao
Abstract excerpt
ARID1A, one of the subunits in SWI/SNF chromatin remodeling complex, is frequently mutated in gastric cancers with microsatellite instability (MSI). The most frequent MSI in solid-type poorly differentiated adenocarcinoma (PDA) has been reported, but the SWI/SNF complex status in solid-type PDA is still largely unknown. We retrospectively analyzed 54 cases of solid-type PDA for the expressions of mismatch repair...
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