SMARCB1-deficient sinonasal adenocarcinoma: a rare variant of SWI/SNF-deficient malignancy often misclassified as high-grade non-intestinal-type sinonasal adenocarcinoma or myoepithelial carcinoma.

doi:10.1007/s00428-023-03650-2

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Article

SMARCB1-deficient sinonasal adenocarcinoma: a rare variant of SWI/SNF-deficient malignancy often misclassified as high-grade non-intestinal-type sinonasal adenocarcinoma or myoepithelial carcinoma.

Virchows Archiv : an international journal of pathology - 1 Aug 2024

Skálová Alena, Taheri Touraj, Bradová Martina, Vaněček Tomáš, Franchi Alessandro, Slouka David, Kostlivý Tomáš, de Rezende Gisele, Michálek Jaroslav, Klubíčková Natálie, Ptáková Nicola, Nemcová Antónia, Michal Michal, Agaimy Abbas, Leivo Ilmo

Abstract excerpt

SMARCB1-deficient sinonasal adenocarcinoma is a rare variant of SWI/SNF-deficient malignancies with SMARCB1 loss and adenocarcinoma features. More than 200 high-grade epithelial sinonasal malignancies were retrieved. A total of 14 cases exhibited complete SMARCB1 (INI1) loss and glandular differentiation. SMARCA2 and SMARCA4 were normal, except for one case with a loss of SMARCA2. Next-generation sequencing (NGS)...

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PMID: 38085333
DOI: 10.1007/s00428-023-03650-2
PMCID: PMC11329539

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