Article
Dedifferentiated/undifferentiated endometrial carcinoma:SWI/SNF-deficiency and molecular heterogeneity indicating novel prognostic stratification in a single-center study of 71 cases.
Human pathology - 1 Sept 2026
Qi Yu, Yao Qianlan, Xu Yuyin, Yu Lin, Tu Xiaoyu, Cheng Yufan, Ge Huijuan, Tang Shaoxian, Zhou Xiaoyan, Yang Wentao, Bi Rui
Abstract excerpt
Deficiency of SWI/SNF proteins, particularly BRG1 (SMARCA4) and INI1 (SMARCB1), has frequently been associated with poor clinical outcomes in dedifferentiated/undifferentiated endometrial carcinoma (DDEC/UDEC). However, the prognostic significance of BRM (SMARCA2) remains unclear. Additionally, although the TCGA classification predicts outcomes in endometrioid adenocarcinoma, its prognostic value in DDEC/UDEC is...
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