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Article

Acute myeloid leukemia immune escape by epigenetic CD48 silencing

1 Jan 2020

Abstract excerpt

Acute myeloid leukemia (AML) is a malignant disorder of hemopoietic stem cells. AML can escape immunosurveillance of natural killer (NK) by gene mutation, fusions and epigenetic modification. The mechanism of AML immune evasion is not clearly understood. Here we show that CD48 high expression is a favorable prognosis factor that is down-regulated in AML patients, which can help AML evade from NK cell recognition...

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PMID: 31922199
DOI: 10.1042/cs20191170

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