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Article

Increased TIGIT expressing NK cells with dysfunctional phenotype in AML patients correlated with poor prognosis.

Cancer immunology, immunotherapy : CII - 1 Feb 2022

Liu Guanfang, Zhang Qi, Yang Jingying, Li Xiaomin, Xian Luhua, Li Wenmin, Lin Ting, Cheng Juan, Lin Qiwen, Xu Xiuzhang, Li Qin, Lin Yu, Zhou Maohua, Shen Erxia

Abstract excerpt

AML is the most common blood cancer in adults with a high relapse and an overall poor survival rate. NK cells have been demonstrated to have the capacity to eradicate AML blast, and an impaired NK cell function is involved in AML development and progression. Immune checkpoints are involved in immune escape in various cancers. Immune checkpoints blockade therapy mainly aimed to unleash CD8+T cells function, but NK...

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Identifiers

PMID: 34129052
DOI: 10.1007/s00262-021-02978-5
PMCID: PMC10991465

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