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Article

Integrated analysis reveals distinct molecular, clinical, and immunological features of B7-H3 in acute myeloid leukemia.

Cancer medicine - 1 Nov 2021

Zhang Ling-Yi, Jin Ye, Xia Pei-Hui, Lin Jiang, Ma Ji-Chun, Li Ting, Liu Zi-Qi, Xiang He-Lin, Cheng Chen, Xu Zi-Jun, Zhou Hong, Qian Jun

Abstract excerpt

The role of B7-H3 in acute myeloid leukemia (AML) is not fully understood. Two previous studies investigating its expression and significances in AML are partially different. In this study, we aimed to systematically characterize the genomic and immune landscape in AML patients with altered B7-H3 expression using multi-omics data in the public domain. We found significantly increased B7-H3 expression in AML...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34562306
DOI: 10.1002/cam4.4284
PMCID: PMC8559480

Genes

CD70
CD80
CD86
TP53
WT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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