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Immune evasion by oncogenic proteins of acute myeloid leukemia

21 Jan 2014

Abstract excerpt

PML-RARA and AML1-ETO are important oncogenic fusion proteins that play a central role in transformation to acute myeloid leukemia (AML). Whether these fusion proteins render the tumor cells with immune evasion properties is unknown. Here we show that both oncogenic proteins specifically downregulate the expression of CD48, a ligand of the natural killer (NK) cell activating receptor 2B4, thereby leading to...

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PMID: 24449212
DOI: 10.1182/blood-2013-09-526590

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