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Article

ABCC2 as a novel covariate influencing oxcarbazepine pharmacokinetics in pediatric epilepsy: Insights from population modeling.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jun 2025

Shen Xianhuan, Zhu Jiahao, He Yaodong, Wang Xixuan, Li Wenzhou, Fan Xiaomei

Abstract excerpt

This study set out to establish a population pharmacokinetic (PPK) model of oxcarbazepine (OXC) in pediatric patients with epilepsy, with the goal of optimizing individualized dosage strategies. We collected steady-state trough plasma concentration data of the OXC active metabolite 10-hydroxycarbazepine from epileptic children. The effects of physiological factors, concomitant medications, and genetic factors on...

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Identifiers

PMID: 40424646
DOI: 10.1016/j.dmd.2025.100090

Genes

ABCC2

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