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Article

TXNIP hypomethylation and its interaction with obesity and hypertriglyceridemia increase type 2 diabetes mellitus risk: A nested case-control study.

Journal of diabetes - 1 Jul 2020

Zhang Dongdong, Cheng Cheng, Cao Meng, Wang Tieqiang, Chen Xiaoliang, Zhao Yang, Wang Bingyuan, Ren Yongcheng, Liu Dechen, Liu Leilei, Chen Xu, Liu Feiyan, Zhou Qionggui, Tian Gang, Li Quanman, Guo Chunmei, Li Honghui, Wang Jian, Cheng Ruirong, Hu Dongsheng, Zhang Ming

Abstract excerpt

BACKGROUND: This study aims to estimate type 2 diabetes mellitus (T2DM) incidence with DNA methylation of the thioredoxin-interacting protein (TXNIP) gene and its interaction with environmental factors. MATERIALS AND METHODS: This case-control study included 286 incident T2DM cases and 286 non-T2DM controls matched by sex, age, marital status, race, and residence village nested in the Rural Chinese Cohort Study....

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Identifiers

PMID: 31919985
DOI: 10.1111/1753-0407.13021

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