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DNA Methylation of TXNIP Independently Associated with Inflammation and Diabetes Mellitus in Twins

1 Oct 2021

Abstract excerpt

Thioredoxin-interacting protein (TXNIP) plays a key role in diabetes development and prognosis through its role in pancreatic β-cell dysfunction and death as well as in upregulating the inflammatory response in hyperglycemia. DNA methylation (DNAm) of TXNIP (TXNIP-cg19693031) is associated with the prevalence and incidence of type 2 diabetes (T2D); however, its role in inflammation and its relationship with T2D...

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PMID: 34726138
DOI: 10.1017/thg.2021.42

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