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Article

Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus.

Diabetic medicine : a journal of the British Diabetic Association - 1 May 2007

van Greevenbroek M M J, Vermeulen V M M-J, Feskens E J M, Evelo C T, Kruijshoop M, Hoebee B, van der Kallen C J H, de Bruin T W A

Abstract excerpt

AIMS: Thioredoxin interacting protein (TXNIP) is an attractive candidate gene for diabetes or diabetic dyslipidaemia, since TXNIP is the strongest glucose-responsive gene in pancreatic B-cells, TXNIP deficiency in a mouse model is associated with hyperlipidaemia and TXNIP is located in the 1q21-1q23 chromosomal Type 2 diabetes mellitus (DM) locus. We set out to investigate whether metabolic effects of TXNIP that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17381501
DOI: 10.1111/j.1464-5491.2007.02109.x

Genes

TXNIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus.PMID 17381501Read ↗

Thioredoxin interacting protein genetic variation is associated with diabetes and hypertension in the Brazilian general population.Semantic proximity Read ↗

TXNIP regulates peripheral glucose metabolism in humans.Semantic proximity Read ↗

TXNIP Gene Single Nucleotide Polymorphisms Associated with the Risk of Type 2 Diabetes Mellitus in a Chinese Han Population.Semantic proximity Read ↗

TXNIP hypomethylation and its interaction with obesity and hypertriglyceridemia increase type 2 diabetes mellitus risk: A nested case-control study.Semantic proximity Read ↗

Genetic variants of thioredoxin interacting protein gene and their association with diabetic peripheral neuropathy in type 2 diabetes mellitus.Semantic proximity Read ↗

DNA Methylation of TXNIP Independently Associated with Inflammation and Diabetes Mellitus in TwinsSemantic proximity Read ↗

TXNIP is a critical regulator of human cardiometabolic healthSemantic proximity Read ↗

Thioredoxin-Interacting Protein Is Stimulated by Glucose through a Carbohydrate Response Element and Induces β-Cell ApoptosisSemantic proximity Read ↗

Minireview: Thioredoxin-Interacting Protein: Regulation and Function in the Pancreatic β-CellSemantic proximity Read ↗

Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition.Semantic proximity Read ↗

Epigenome-wide association study identifies<i>TXNIP</i>gene associated with type 2 diabetes mellitus and sustained hyperglycemiaSemantic proximity Read ↗

Associations of polymorphisms in TXNIP and gene-environment interactions with the risk of coronary artery disease in a Chinese Han population.Semantic proximity Read ↗

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