Article
Visit to visit transition in TXNIP gene methylation and the risk of type 2 diabetes mellitus: a nested case-control study.
Journal of human genetics - 1 Jul 2024
Wu Yuying, Chen Weiling, Zhao Yang, Gu Minqi, Gao Yajuan, Ke Yamin, Wang Longkang, Wang Mengmeng, Zhang Wenkai, Chen Yaobing, Huo Weifeng, Fu Xueru, Li Xi, Zhang Dongdong, Qin Pei, Hu Fulan, Liu Yu, Sun Xizhuo, Zhang Ming, Hu Dongsheng
Abstract excerpt
Our study aimed to investigate the association between the transition of the TXNIP gene methylation level and the risk of incident type 2 diabetes mellitus (T2DM). This study included 263 incident cases of T2DM and 263 matched non-T2DM participants. According to the methylation levels of five loci (CpG1-5; chr1:145441102-145442001) on the TXNIP gene, the participants were classified into four transition groups:...
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