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Integrated analysis of probability of type 2 diabetes mellitus with polymorphisms and methylation of SLC30A8 gene: a nested case-control study.

Journal of human genetics - 1 Nov 2022

Hu Fulan, Zhang Yanyan, Qin Pei, Zhao Yang, Liu Dechen, Zhou Qionggui, Tian Gang, Li Quanman, Guo Chunmei, Wu Xiaoyan, Qie Ranran, Huang Shengbing, Han Minghui, Li Yang, Hu Dongsheng, Zhang Ming

Abstract excerpt

To estimate the associations between single-nucleotide polymorphisms (SNPs) and methylation of SLC30A8 gene and T2DM risk, and the interactions among SNPs, methylation, and environmental factors on T2DM risk. We genotyped 9 SNPs and tested methylation at 46 CpG loci of SLC30A8 in the baseline DNA of 290 T2DM cases and 290 matched controls nested in the Rural Chinese Cohort Study. A conditional logistic regression...

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PMID: 35996015
DOI: 10.1038/s10038-022-01067-4

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