Association of TCF7L2 gene polymorphisms, methylation, and gene-environment interaction with type 2 diabetes mellitus risk: A nested case-control study in the Rural Chinese Cohort Study.

doi:10.1016/j.jdiacomp.2020.107829

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Article

Association of TCF7L2 gene polymorphisms, methylation, and gene-environment interaction with type 2 diabetes mellitus risk: A nested case-control study in the Rural Chinese Cohort Study.

Journal of diabetes and its complications - 1 Mar 2021

Qie Ranran, Han Minghui, Huang Shengbing, Li Quanman, Liu Leilei, Zhang Dongdong, Cheng Cheng, Zhao Yang, Liu Dechen, Qin Pei, Guo Chunmei, Zhou Qionggui, Tian Gang, Zhang Yanyan, Wu Xiaoyan, Wu Yuying, Li Yang, Yang Xingjin, Zhao Yang, Feng Yifei, Hu Fulan, Zhang Ming, Hu Dongsheng, Lu Jie

Abstract excerpt

BACKGROUND: To assess the associations of single-nucleotide polymorphisms (SNPs) and methylation of transcription factor 7-like 2 (TCF7L2) gene with type 2 diabetes mellitus (T2DM) risk and further explore the interactions among SNPs, methylation, and environmental factors involved in T2DM risk. METHODS: We conducted a nested case-control study with 290 pairs of T2DM cases and matched controls. We genotyped 3...

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PMID: 33419631
DOI: 10.1016/j.jdiacomp.2020.107829

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