Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization.

Scientific reports - 9 Jan 2020

Martinez Stephanie E, Andresen Marie C, Zhu Zhaohui, Papageorgiou Ioannis, Court Michael H

Abstract excerpt

Greyhounds recover more slowly from certain injectable anesthetics than other dog breeds. Previous studies implicate cytochrome P450 (CYP) 2B11 as an important clearance mechanism for these drugs and suggest Greyhounds are deficient in CYP2B11. However, no CYP2B11 gene mutations have been identified that explain this deficiency in Greyhounds. The objectives of this study were to provide additional evidence for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P450 Family 2

Share to Microsomes, Liver

Share to Pharmacogenetics

Share to Propofol

Share to RNA Splicing

Share to Steroid Hydroxylases

Source

Open in PubMed Open full text

Identifiers

PMID: 31919457
DOI: 10.1038/s41598-019-56660-z
PMCID: PMC6952448

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization.PMID 31919457Read ↗

Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization.Semantic proximity Read ↗

Genetic variants in dog cytochrome P450 2B6 and their relevance to interindividual variability of oxidations of probe drug propofol.Semantic proximity Read ↗

SNP genetic polymorphisms of MDR-1, CYP1A2 and CYPB11 genes in four canine breeds upon toxicological evaluation.Semantic proximity Read ↗

Pharmacogenetics of opioid analgesics in dogs.Semantic proximity Read ↗

Implications of ABC transporters on the disposition of typical veterinary medicinal products.Semantic proximity Read ↗

Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p -nitrophenolSemantic proximity Read ↗

A single-nucleotide polymorphism in the canine cytochrome b5 reductase (CYB5R3) gene is associated with sulfonamide hypersensitivity and is overrepresented in Doberman Pinschers.Semantic proximity Read ↗

Genetic variants of cytochrome P450 2C21 identified by screening 6344 dogs influenced oxidations of the probe drug omeprazole.Semantic proximity Read ↗

Cloning of canine cytochrome P450 2E1 cDNA: identification and characterization of two variant alleles.Semantic proximity Read ↗

ABCG2 transporter: therapeutic and physiologic implications in veterinary speciesSemantic proximity Read ↗

Equine cytochrome P450 2B6--genomic identification, expression and functional characterization with ketamine.Semantic proximity Read ↗

Phenacetin pharmacokinetics in CYP1A2-deficient beagle dogs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.