Article
Genetic variants in dog cytochrome P450 2B6 and their relevance to interindividual variability of oxidations of probe drug propofol.
Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2025
Uno Yasuhiro, Fukunaga Koya, Ushirozako Genki, Murayama Norie, Mizukami Keijiro, Aoi Tomomi, Tomiyasu Hirotaka, Honnami Muneki, Tsujimoto Hajime, Sakaguchi Masahiro, Hisasue Masaharu, Mushiroda Taisei, Momozawa Yukihide, Yamazaki Hiroshi
Abstract excerpt
The cytochromes P450 (P450s) are essential drug-metabolizing enzymes. In humans, P450 genetic variants partly account for interindividual variability in drug metabolism. However, in dogs, a species often used in drug metabolism studies, the genetic variants of P450s remain to be fully investigated. In this study, the sequencing of 6344 dog genomes identified 8 variants in CYP2B6 (formerly CYP2B11), including 7...
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