Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenacetin pharmacokinetics in CYP1A2-deficient beagle dogs.

Drug metabolism and disposition: the biological fate of chemicals - 1 Feb 2012

Whiterock Valerie J, Morgan Daniel G, Lentz Kimberley A, Orcutt Tami L, Sinz Michael W

Abstract excerpt

Phenacetin is widely used as an in vitro probe to measure CYP1A2 activity across species. To investigate whether phenacetin can be used as an in vivo probe substrate to phenotype CYP1A2 activity in dogs, beagle dogs previously genotyped for a single nucleotide polymorphism that yields an inactive CYP1A2 protein were selected and placed into one of three groups: CC (wild-type), CT (heterozygous), or TT (homozygous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetaminophen
Share to Analgesics, Non-Narcotic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biotransformation

Share to Codon, Terminator

Share to Cytochrome P-450 CYP1A2

Share to Half-Life

Share to Infusions, Intravenous

Share to Metabolic Clearance Rate

Source

Identifiers

PMID: 22074769
DOI: 10.1124/dmd.111.041848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenacetin pharmacokinetics in CYP1A2-deficient beagle dogs.PMID 22074769Read ↗

Identification of non-functional allelic variant of CYP1A2 in dogs.Semantic proximity Read ↗

Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization.Semantic proximity Read ↗

Identification of the novel canine CYP1A2 1117 C > T SNP causing protein deletion.Semantic proximity Read ↗

Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes.Semantic proximity Read ↗

ABCG2 transporter: therapeutic and physiologic implications in veterinary speciesSemantic proximity Read ↗

Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity.Semantic proximity Read ↗

Frequency of CYP1A2 polymorphism in beagle dogs.Semantic proximity Read ↗

Implications of ABC transporters on the disposition of typical veterinary medicinal products.Semantic proximity Read ↗

Pharmacogenetics of opioid analgesics in dogs.Semantic proximity Read ↗

Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogs.Semantic proximity Read ↗

Polymorphic expression of CYP1A2 leading to interindividual variability in metabolism of a novel benzodiazepine receptor partial inverse agonist in dogs.Semantic proximity Read ↗

Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.