Article
Pharmacogenetics of opioid analgesics in dogs.
Journal of veterinary pharmacology and therapeutics - 1 Apr 2018
Kongara K
Abstract excerpt
Genetic variation causes interindividual variability in drug absorption, distribution, metabolism and excretion. These pharmacokinetic processes will influence the observed efficacy and toxicity of a drug. Polymorphisms in the genes encoding the metabolizing enzymes, transport proteins and receptors have been linked to the inconsistency in responses to opioid treatment in humans and laboratory animals....
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