Article
Genetic variants of cytochrome P450 2C21 identified by screening 6344 dogs influenced oxidations of the probe drug omeprazole.
Biochemical pharmacology - 1 Dec 2025
Uno Yasuhiro, Fukunaga Koya, Ushirozako Genki, Murayama Norie, Mizukami Keijiro, Aoi Tomomi, Tomiyasu Hirotaka, Honnami Muneki, Tsujimoto Hajime, Sakaguchi Masahiro, Hisasue Masaharu, Mushiroda Taisei, Momozawa Yukihide, Yamazaki Hiroshi
Abstract excerpt
The cytochromes P450 (P450s or CYPs) are essential drug-metabolizing enzymes. In humans, the variability in metabolic activity is partly accounted for by genetic variants of the responsible P450. However, P450 genetic variants remain largely to be investigated in dogs, a species often used in drug metabolism studies. In this study, the sequencing of 6344 dog genomes found five CYP2C21 variants, including three...
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