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ABCG2 transporter: therapeutic and physiologic implications in veterinary species

6 Jun 2011

Abstract excerpt

Drug transporters significantly influence drug pharmacokinetics and pharmacodynamics. While P-glycoprotein, the product of the MDR1 (ABCB1) gene, is the most well-characterized ABC transporter, the pharmacological importance of a related transporter, ABCG2, is starting to be realized in veterinary medicine. Based primarily on human and rodent studies, a number of clinically relevant, structurally and functionally...

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PMID: 21645015
DOI: 10.1111/j.1365-2885.2011.01313.x

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