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Article

Interferon mediated neuroinflammation in polyglutamine disease is not caused by RNA toxicity.

Cell death & disease - 2 Jan 2020

Bhambri Aksheev, Pinto Akeeth, Pillai Beena

Abstract excerpt

Polyglutamine diseases are neurodegenerative diseases that occur due to the expansion of CAG repeat regions in coding sequences of genes. Previously, we have shown the formation of large protein aggregates along with activation of the interferon pathway leading to apoptosis in a cellular model of SCA17. Here, we corroborate our previous results in a tetracycline-inducible model of SCA17. Interferon gamma and...

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Identifiers

PMID: 31919387
DOI: 10.1038/s41419-019-2193-x
PMCID: PMC6952400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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