Article
TATA-binding protein in neurodegenerative disease.
Neuroscience - 1 Jan 2005
van Roon-Mom W M C, Reid S J, Faull R L M, Snell R G
Abstract excerpt
TATA binding protein (TBP) is a general transcription factor that plays an important role in initiation of transcription. In recent years evidence has emerged implicating TPB in the molecular mechanism of a number of neurodegenerative diseases. Wild type TBP in humans contains a long polyglutamine stretch ranging in size from 29 to 42. It has been found associated with aggregated proteins in several of the...
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