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Article

Regulation of BACE1 by miR-29a/b in a cellular model of Spinocerebellar ataxia 17

1 Jun 2012

Abstract excerpt

Polyglutamine diseases are a class of neurodegenerative disorders characterized by expansion of polyglutamine repeats, protein aggregation and neuronal cell death in specific regions of the brain. The expansion of a polyglutamine repeat in the TATA binding protein (TBP) causes a neurodegenerative disease, Spinocerebellar Ataxia 17 (SCA17). This disease is characterized by intranuclear protein aggregates and...

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PMID: 22664922
DOI: 10.4161/rna.19876

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