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Article

Spinocerebellar ataxias caused by polyglutamine expansions: a review of therapeutic strategies.

Cerebellum (London, England) - 1 Jan 2008

Underwood Benjamin R, Rubinsztein David C

Abstract excerpt

Six of the spinocerebellar ataxias (SCAs) are caused by expanded CAG trinucleotide repeats encoding polyglutamine tracts in different genes. Together with three other neurodegenerative diseases they represent the polyglutamine repeat disorders. These disorders share many pathological features beyond a common genetic mechanism. They are the subject of considerable research efforts to elucidate their basic...

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PMID: 18418676
DOI: 10.1007/s12311-008-0026-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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