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Article

Molecular investigation of TBP allele length: a SCA17 cellular model and population study.

Neurobiology of disease - 1 Jun 2003

Reid Suzanne J, Rees Mark I, van Roon-Mom Willeke M C, Jones A Lesley, MacDonald Marcy E, Sutherland Greg, During Matthew J, Faull Richard L M, Owen Michael J, Dragunow Mike, Snell Russell G

Abstract excerpt

Recently, an inherited spinocerebellar ataxia (SCA17) has been attributed to polyglutamine coding expansions within the gene coding for human TATA-box binding protein (TBP). The normal repeat range is 25-42 units with patients having as few as 46 repeats. We undertook a TBP repeat length population study showing its relative stability, skewed distribution, and substantial population specific differences. To...

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Source

Identifiers

PMID: 12758065
DOI: 10.1016/s0969-9961(03)00014-7

Genes

TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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