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Article

Effect of tolerance on the evolution of antibiotic resistance under drug combinations.

Science (New York, N.Y.) - 10 Jan 2020

Liu Jiafeng, Gefen Orit, Ronin Irine, Bar-Meir Maskit, Balaban Nathalie Q

Abstract excerpt

Drug combinations are widely used in clinical practice to prevent the evolution of resistance. However, little is known about the effect of tolerance, a different mode of survival, on the efficacy of drug combinations for preventing the evolution of resistance. In this work, we monitored Staphylococcus aureus strains evolving in patients under treatment. We detected the rapid emergence of tolerance mutations,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 31919223
DOI: 10.1126/science.aay3041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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