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Article

Distinctive variation in the U3R region of the 5' Long Terminal Repeat from diverse HIV-1 strains.

PloS one - 1 Jan 2018

Mbondji-Wonje Christelle, Dong Ming, Wang Xue, Zhao Jiangqin, Ragupathy Viswanath, Sanchez Ana M, Denny Thomas N, Hewlett Indira

Abstract excerpt

Functional mapping of the 5'LTR has shown that the U3 and the R regions (U3R) contain a cluster of regulatory elements involved in the control of HIV-1 transcription and expression. As the HIV-1 genome is characterized by extensive variability, here we aimed to describe mutations in the U3R from various HIV-1 clades and CRFs in order to highlight strain specific differences that may impact the biological...

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Share to Evolution, Molecular
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Viral

Share to HIV Infections

Share to HIV Long Terminal Repeat

Share to Recombination, Genetic

Share to Transcription, Genetic

Source

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Identifiers

PMID: 29664930
DOI: 10.1371/journal.pone.0195661
PMCID: PMC5903597

Genes

EBP

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