Article
Genetic variation of the HIV-1 subtype C transmitted/founder viruses long terminal repeat elements and the impact on transcription activation potential and clinical disease outcomes.
PLoS pathogens - 1 Jun 2023
Madlala Paradise, Mkhize Zakithi, Naicker Shamara, Khathi Samukelisiwe P, Maikoo Shreyal, Gopee Kasmira, Dong Krista L, Ndung'u Thumbi
Abstract excerpt
A genetic bottleneck is a hallmark of HIV-1 transmission such that only very few viral strains, termed transmitted/founder (T/F) variants establish infection in a newly infected host. Phenotypic characteristics of these variants may determine the subsequent course of disease. The HIV-1 5' long terminal repeat (LTR) promoter drives viral gene transcription and is genetically identical to the 3' LTR. We...
Topics
- Humans
- Transcriptional Activation
- HIV-1
- Transcription, Genetic
- tat Gene Products, Human Immunodeficiency Virus
- Tumor Necrosis Factor-alpha
- HIV Long Terminal Repeat
- Genetic Variation
- HIV Infections
- Gene Expression Regulation, Viral