Article
Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons.
Cell reports - 26 Mar 2024
Wu Jing, Quraishi Imran H, Zhang Yalan, Bromwich Mark, Kaczmarek Leonard K
Abstract excerpt
The KCNT1 gene encodes the sodium-activated potassium channel Slack (KCNT1, KNa1.1), a regulator of neuronal excitability. Gain-of-function mutations in humans cause cortical network hyperexcitability, seizures, and severe intellectual disability. Using a mouse model expressing the Slack-R455H mutation, we find that Na+-dependent K+ (KNa) and voltage-dependent sodium (NaV) currents are increased in both...
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