Article

Symmetry Analysis and Ancestral Sequence Reconstruction Reveal a Symmetrical Translocation Pathway and Activity Determinants of ZIP Metal Transporter

2026-05-15

Abstract excerpt

Membrane transporters frequently exhibit internal structural symmetry, reflecting evolutionary origins through gene duplication and fusion events, and this feature has been widely used to infer transport mechanisms. Yet its application to the ZIP (Zrt-/Irt-like protein) family of divalent metal transporters, which are crucial for trace metal homeostasis, has not been fully explored. Here, we apply combined symmetr...

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Literature Corpus work: e8348535-cbb5-5263-8919-eff70afe9ece
DOI: 10.64898/2026.05.13.724914

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Symmetry Analysis and Ancestral Sequence Reconstruction Reveal a Symmetrical Translocation Pathway and Activity Determinants of ZIP Metal TransporterDOI 10.64898/2026.05.13.724914Read

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