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Article

Structural insights of ZIP4 extracellular domain critical for optimal zinc transport.

Nature communications - 20 Jun 2016

Zhang Tuo, Sui Dexin, Hu Jian

Abstract excerpt

The ZIP zinc transporter family is responsible for zinc uptake from the extracellular milieu or intracellular vesicles. The LIV-1 subfamily, containing nine out of the 14 human ZIP proteins, is featured with a large extracellular domain (ECD). The critical role of the ECD is manifested by disease-causing mutations on ZIP4, a representative LIV-1 protein. Here we report the first crystal structure of a mammalian...

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Identifiers

PMID: 27321477
DOI: 10.1038/ncomms11979
PMCID: PMC4915132

Genes

ECD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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