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The two-domain elevator-type mechanism of zinc-transporting ZIP proteins

13 Jul 2022

Abstract excerpt

Zinc is essential for all organisms and yet detrimental at elevated levels. Hence, homeostasis of this metal is tightly regulated. The Zrt/Irt-like proteins (ZIPs) represent the only zinc importers in metazoans. Mutations in human ZIPs cause serious disorders, but the mechanism by which ZIPs transfer zinc remains elusive. Hitherto, structural information is only available for a model member, BbZIP, and as a...

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PMID: 35857505
DOI: 10.1126/sciadv.abn4331

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