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Article

Two-stage Bayesian GWAS of 9576 individuals identifies SNP regions that are targeted by miRNAs inversely expressed in Alzheimer's and cancer.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2020

Pathak Gita A, Zhou Zhengyang, Silzer Talisa K, Barber Robert C, Phillips Nicole R

Abstract excerpt

INTRODUCTION: We compared genetic variants between Alzheimer's disease (AD) and two age-related cancers-breast and prostate -to identify single-nucleotide polymorphisms (SNPs) that are associated with inverse comorbidity of AD and cancer. METHODS: Bayesian multinomial regression was used to compare sex-stratified cases (AD and cancer) against controls in a two-stage study. A ±500 KB region around each replicated...

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Source

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Identifiers

PMID: 31914222
DOI: 10.1002/alz.12003
PMCID: PMC13221707

Genes

APOC1
APOE
CLPTM1
FSTL4
MARK4
TOMM40
VDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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