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Article

Spontaneous mutagenesis in human cells is controlled by REV1-Polymerase ζ and PRIMPOL.

Cell reports - 29 Aug 2023

Gyüre Zsolt, Póti Ádám, Németh Eszter, Szikriszt Bernadett, Lózsa Rita, Krawczyk Michał, Richardson Andrea L, Szüts Dávid

Abstract excerpt

Translesion DNA synthesis (TLS) facilitates replication over damaged or difficult-to-replicate templates by employing specialized DNA polymerases. We investigate the effect on spontaneous mutagenesis of three main TLS control mechanisms: REV1 and PCNA ubiquitylation that recruit TLS polymerases and PRIMPOL that creates post-replicative gaps. Using whole-genome sequencing of cultured human RPE-1 cell clones, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37498746
DOI: 10.1016/j.celrep.2023.112887

Genes

REV1
PRIMPOL
PCNA
REV3L
RPE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Spontaneous mutagenesis in human cells is controlled by REV1-Polymerase ζ and PRIMPOL.PMID 37498746Read ↗

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