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The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells

2 Jan 2020

Abstract excerpt

Abstract Background Evasion from programmed cell death is a hallmark of cancer and can be achieved in cancer cells by overexpression of inhibitor of apoptosis proteins (IAPs). Second mitochondria-derived activator of caspases (SMAC) directly bind to IAPs and promote apoptosis; thus, SMAC mimetics have been investigated in a variety of cancer types. particularly in diseases with high inflammation and NFĸB...

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PMID: 31908904
DOI: 10.1186/s40164-019-0157-6

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